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Theoretical insights into influence of additives on sulfamethoxazole crystal growth kinetics and mechanisms

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 10,   Pages 1503-1515 doi: 10.1007/s11705-022-2294-4

Abstract: In this work, the influence of the initial chemical potential gradient, stirring speed, and polymer type on sulfamethoxazole (SMX) crystal growth kinetics was systematically investigated through density functional theory (DFT) calculations, experimental measurements and the two-step chemical potential gradient model. To investigate the influence of different conditions on the thermodynamic driving force of SMX crystal growth, SMX solubilities in different polymer solutions were studied. Four model polymers effectively improved SMX solubility. It was further found that polyvinylpyrrolidone (PVP) and hydroxypropyl methyl cellulose (HPMC) played a crucial role in inhibiting SMX crystal growth. However, polyethylene glycol (PEG) promoted SMX crystal growth. The effect of the polymer on the crystal growth mechanisms of SMX was further analyzed by the two-step chemical potential gradient model. In the system containing PEG 6000, crystal growth is dominated by the surface reaction. However, in the system containing PEG 20000, crystal growth is dominated by both the surface reaction and diffusion. In addition, DFT calculations results showed that HPMC and PVP could form strong and stable binding energies with SMX, indicating that PVP and HPMC had the potential ability to inhibit SMX crystal growth.

Keywords： insoluble drugs     polymer     inhibition crystallization     crystal growth kinetics     DFT calculations    

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Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosisthrough inhibition of transforming growth factor β-induced Smad signaling

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 445-455 doi: 10.1007/s11684-014-0378-3

Abstract: PDE5 inhibition prevents cardiac fibrosis by reducing CBP1 recruitment to Smad transcriptional complexes

Keywords： PDE5     cardiac fibrosis     TGF-β     CREB    

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Progress in membrane distillation crystallization: Process models, crystallization control and innovative

Xiaobin Jiang, Linghan Tuo, Dapeng Lu, Baohong Hou, Wei Chen, Gaohong He

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 647-662 doi: 10.1007/s11705-017-1649-8

Abstract: Membrane distillation crystallization (MDC) is a promising hybrid separation process that has been appliedprogress has been made in MDC technologies including the promotion of nucleation and better control of crystallizationThis review focuses on the development of MDC process models and on crystallization control strategies

Keywords： membrane distillation crystallization     mathematics model     nucleation     separation     hybrid process    

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Effects of a structurally related substance on the crystallization of paracetamol

Ali SALEEMI, I.I. ONYEMELUKWE, Zoltan NAGY

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1,   Pages 79-87 doi: 10.1007/s11705-013-1308-7

Abstract: Small amounts of metacetamol (1–4 mol-%) were found to cause significant inhibition to the nucleation

Keywords： acetaminophen     metacetamol     crystallization     metastable zone width     induction time     supersaturation control    

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Interfacial induction and regulation for microscale crystallization process: a critical review

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 6,   Pages 838-853 doi: 10.1007/s11705-021-2129-8

Abstract: Microscale crystallization is at the frontier of chemical engineering, material science, and biochemicalstructure and cavities, pore shape and pore size, surface porosity, channels), in various microscale crystallizationfuture research and development directions are outlined to emphasize the importance of interfacial crystallization

Keywords： interfacial crystallization     heterogeneous nucleation     supersaturation     micro/nanostructure     process    

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simultaneous anammox and denitrification system with short-term pyridine exposure: Process capability, inhibition

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 6, doi: 10.1007/s11783-021-1433-3

Abstract:

• Short-term effect of the pyridine exposure on the SAD process was investigated.

Keywords： Anammox     Inhibition     Metabolic pathway     Microbial community     Pyridine     SAD    

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ROOT EXUDATES FROM CANOLA EXHIBIT BIOLOGICAL NITRIFICATION INHIBITION AND ARE EFFECTIVE IN INHIBITING

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 2,   Pages 177-186 doi: 10.15302/J-FASE-2021421

Abstract: This biological nitrification inhibition (BNI) capacity can decrease N loss and increase N uptake fromRoot exudates were collected and their inhibition of the ammonia oxidizing bacterium, NitrosospiraSubsequent pot experiments were used to test the inhibition of native nitrifying communities in soil.The level of nitrification inhibition across the three cultivars was similar to the well-studied high-BNI

Keywords： ammonia oxidizing microorganisms / biological nitrification inhibition / farming rotations / nitrogen    

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Inhibition character of crotonaldehyde manufacture wastewater on biological acidification

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 6, doi: 10.1007/s11783-021-1403-9

Abstract:

• The inhibition of the main organic pollutions in CMW was demonstrated

Keywords： Crotonaldehyde manufacture wastewater     Biological acidification     Volatile fatty acids     Inhibition     Toxic    

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Roles of integrin β3 cytoplasmic tail in bidirectional signal transduction in a trans-dominant inhibition

Jiansong Huang,Yulan Zhou,Xiaoyu Su,Yuanjing Lyu,Lanlan Tao,Xiaofeng Shi,Ping Liu,Zhangbiao Long,Zheng Ruan,Bing Xiao,Wenda Xi,Quansheng Zhou,Jianhua Mao,Xiaodong Xi

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 311-319 doi: 10.1007/s11684-016-0460-0

Abstract: beta;3 cytoplasmic tail in integrin αIIbβ3 bidirectional signaling using a trans-dominant inhibition

Keywords： integrin β3     signal transduction     trans-dominant inhibition model    

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The feasibility of coating by cooling crystallization on ibuprofen naked tablets

Fatima Mameri, Ouahiba Koutchoukali, Mohamed Bouhelassa, Anne Hartwig, Leila Nemdili, Joachim Ulrich

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 2,   Pages 211-219 doi: 10.1007/s11705-017-1619-1

Abstract: Recently, a new process of coating by cooling crystallization has been developed and applied on bisacodylpastilles obtained by melt crystallization.In this work, we investigated the feasibility of coating by cooling crystallization on ibuprofen “nakedbeen determined experimentally for the coating solution because they are essential factors for any crystallizationThe results show that naked tablet coating by cooling crystallization is feasible and can be applied

Keywords： coating     solution crystallization     ibuprofen tablets     sucrose    

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Head-to-tail cyclization of a heptapeptide eliminates its cytotoxicity and significantly increases its inhibition

Shuai Ma, Huan Zhang, Xiaoyan Dong, Linling Yu, Jie Zheng, Yan Sun

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 2,   Pages 283-295 doi: 10.1007/s11705-017-1687-2

Abstract: Inhibition of A fibrillation is thus a promising therapeutic approach to the prevention and treatment

Keywords： Alzheimer’s disease     amyloid β-protein     cyclic peptide     inhibition     protein aggregation    

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Utilizing melt crystallization fundamentals in the development of a new tabletting technology

Ahmed ABOUZEID,Sandra PETERSEN,Joachim ULRICH

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 3,   Pages 346-352 doi: 10.1007/s11705-014-1443-9

Abstract: Increasing production effeciency and lowering costs are some of the many advantages melt crystallizationMelt crystallization is a purification (separation) process.

Keywords： phase separation     melt crystallization     tablets     process optimization    

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Nucleic acid crystallization and X-ray crystallography facilitated by single selenium atom

Wen Zhang,Jack W. Szostak,Zhen Huang

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 196-202 doi: 10.1007/s11705-016-1565-3

Abstract: However, the crystallization and phase determination are the major bottle-neck problems in crystallographystrategies to solve the phase determination problem, but also offer a potential strategy to explore crystallization

Keywords： selenium     DNA     RNA     nucleic acid     crystallization    

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Preparation and crystallization kinetics of micron-sized Mg(OH)

Xingfu SONG, Kefeng TONG, Shuying SUN, Ze SUN, Jianguo YU

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 2,   Pages 130-138 doi: 10.1007/s11705-013-1332-7

Abstract: Furthermore, the crystallization kinetics based on the population balance theory was studied to provide

Keywords： magnesium hydroxide     precipitation     micron-sized     crystallization kinetics    

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Applications of the crystallization process in the pharmaceutical industry

Sohrab ROHANI

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 2-9 doi: 10.1007/s11705-009-0297-z

Abstract: The applications of the crystallization technique in the pharmaceutical industry as a purification andexternal control in the form of feedback and real-time optimal control using cooling and antisolvent crystallizationTwo methods to prepare micron-sized drug particles, namely, micro-crystallization and polymer-coatedResolution of chloromandelic acid derivatives, a racemic compound, is achieved using direct crystallizationand diastereomeric salts crystallization.

Keywords： feedback     morphology     pulmonary     paracetamol     recognition    

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Title Author Date Type Operation

Theoretical insights into influence of additives on sulfamethoxazole crystal growth kinetics and mechanisms

Journal Article

Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosisthrough inhibition of transforming growth factor β-induced Smad signaling

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Journal Article

Progress in membrane distillation crystallization: Process models, crystallization control and innovative

Xiaobin Jiang, Linghan Tuo, Dapeng Lu, Baohong Hou, Wei Chen, Gaohong He

Journal Article

Effects of a structurally related substance on the crystallization of paracetamol

Ali SALEEMI, I.I. ONYEMELUKWE, Zoltan NAGY

Journal Article

Interfacial induction and regulation for microscale crystallization process: a critical review

Journal Article

simultaneous anammox and denitrification system with short-term pyridine exposure: Process capability, inhibition

Journal Article

ROOT EXUDATES FROM CANOLA EXHIBIT BIOLOGICAL NITRIFICATION INHIBITION AND ARE EFFECTIVE IN INHIBITING

Journal Article

Inhibition character of crotonaldehyde manufacture wastewater on biological acidification

Journal Article

Roles of integrin β3 cytoplasmic tail in bidirectional signal transduction in a trans-dominant inhibition

Jiansong Huang,Yulan Zhou,Xiaoyu Su,Yuanjing Lyu,Lanlan Tao,Xiaofeng Shi,Ping Liu,Zhangbiao Long,Zheng Ruan,Bing Xiao,Wenda Xi,Quansheng Zhou,Jianhua Mao,Xiaodong Xi

Journal Article

The feasibility of coating by cooling crystallization on ibuprofen naked tablets

Fatima Mameri, Ouahiba Koutchoukali, Mohamed Bouhelassa, Anne Hartwig, Leila Nemdili, Joachim Ulrich

Journal Article

Head-to-tail cyclization of a heptapeptide eliminates its cytotoxicity and significantly increases its inhibition

Shuai Ma, Huan Zhang, Xiaoyan Dong, Linling Yu, Jie Zheng, Yan Sun

Journal Article

Utilizing melt crystallization fundamentals in the development of a new tabletting technology

Ahmed ABOUZEID,Sandra PETERSEN,Joachim ULRICH

Journal Article

Nucleic acid crystallization and X-ray crystallography facilitated by single selenium atom

Wen Zhang,Jack W. Szostak,Zhen Huang

Journal Article

Preparation and crystallization kinetics of micron-sized Mg(OH)

Xingfu SONG, Kefeng TONG, Shuying SUN, Ze SUN, Jianguo YU

Journal Article

Applications of the crystallization process in the pharmaceutical industry

Sohrab ROHANI

Journal Article